Red Española Mastocitosis Score (REMA)

Is this anaphylaxis driven by clonal mast-cell disease?

REMA Score

Gender

• Male:
  • +1 point
• Female:
  • -1 point

Clinical Symptoms

• Pruritus/Hives/Angioedema:
  • Presence (-2)
  • Absence (+1)
• Presyncope/Syncope:
  • Presence (+3) 

Serum Tryptase

• Serum Tryptase:
  • <15 µg/l (-1)
  • >25 µg/l (+2)

Score Interpretation

• Score ≥2 = A high likelihood of clonal mast cells, often prompting a bone marrow biopsy to rule out systemic mastocytosis.
• Score <2 = May suggest other diagnostics like KIT mutation analysis or hereditary alpha-tryptasemia testing are needed